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Potential Benefits of Psilocybin for Lupus Pain

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Daniel Arkfeld suggests that psilocybin could provide long-lasting pain relief for Lupus patients. Further studies on this topic are warranted.

Image courtesy of interviewee. December 5, 2023

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This video video discusses a case study involving the use of psilocybin (found in "magic mushrooms") in treating pain associated with lupus, an autoimmune disorder where the body attacks itself instead of fighting infections. The speaker notes that lupus can be life-threatening and cause significant pain and fatigue.

They explain that while psilocybin research has primarily focused on microdosing for psychiatric benefits, a patient who took a macro dose of six grams—far above the typical microdosing range—experienced relief from chronic pain, despite having a negative trip. This video video case is presented as a significant finding, as it is the first documented instance of psilocybin potentially benefiting lupus-related pain.

Key observations include the importance of dosage, with higher doses potentially needed for pain relief, and the necessity of careful monitoring due to risks of adverse psychological effects. The speaker advocates for more research into psilocybin's therapeutic potential, especially for chronic pain management, while also advising against self-treatment and highlighting the legal status of psilocybin in various states.

Overall, the case demonstrates a promising, albeit preliminary, link between psilocybin and pain relief in autoimmune conditions, suggesting a need for further studies to explore this relationship.

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Here are some articles that are similar in theme and content to the video about psilocybin and its potential therapeutic uses, particularly in relation to autoimmune disorders like lupus:

1. **"Psilocybin and Chronic Pain: New Perspectives"**
This article explores the recent research on psilocybin and its potential effects on chronic pain management. It reviews various studies that investigate dosages and outcomes, focusing on how psychedelics might alter pain perception and provide relief.

2. **"The Role of Psychedelics in Treating Autoimmune Disorders"**
This article discusses how psychedelics, including psilocybin, are being examined for their influence on autoimmune diseases such as lupus and rheumatoid arthritis. It highlights case studies and emerging research that suggest a connection between psychedelics and immune response modulation.

3. **"Psychedelics as Therapeutics: Understanding the Science"**
This comprehensive review examines the scientific background of psilocybin and other psychedelics in treating mental health disorders and chronic pain. It addresses the challenges of dosing, potential benefits, and risks associated with psychedelic use in therapeutic settings.

4. **"Understanding Lupus: New Treatments on the Horizon"**
Focusing specifically on lupus, this article discusses various treatment options, including innovative therapies that investigate the use of psychedelics. It provides insights into autoimmune mechanisms and the complexity of managing chronic pain associated with lupus.

5. **"Microdosing vs. Macrodosing: What Works Best for Pain Relief?"**
In this article, the differences between microdosing and macrodosing psychedelics are explored, specifically in the convideo of pain relief. It analyzes patient experiences, research findings, and suggests directions for future studies.

6. **"Clinical Trials of Psilocybin: Implications for Pain Management"**
This piece reviews ongoing clinical trials that involve psilocybin and their implications for pain management, including chronic conditions such as fibromyalgia and lupus. It emphasizes the need for rigorous research to understand proper dosing and therapeutic outcomes.

7. **"Legal Status of Psilocybin: Impacts on Research and Treatment"**
This article discusses the legal landscape surrounding psilocybin in different regions, its implications for research, and the challenges faced by patients and advocates in accessing psychedelic therapy for conditions like lupus.

These articles collectively provide a broader convideo on the use of psilocybin and other psychedelics in medical research, especially relating to chronic pain and autoimmune disorders.

X-TIMESTAMP-MAP:LOCAL=00:00:00.000,MPEGTS=900000

00:00.105 --> 00:02.315
Yeah, so lupus is a common disorder

00:02.315 --> 00:03.635
that we treat in rheumatology.

00:04.335 --> 00:07.075
Uh, essentially it's where the body, instead

00:07.075 --> 00:09.875
of fighting off an infection for, unclear reasons,

00:09.885 --> 00:11.955
turns on itself and tends to attack itself.

00:12.455 --> 00:16.115
Uh, it can be very much, life-threatening, affecting,

00:16.255 --> 00:17.595
major organ involvement.

00:17.895 --> 00:19.875
It can also cause a significant amount of pain

00:19.875 --> 00:21.675
and fatigue, as in, this case

00:21.675 --> 00:22.995
that we'll be, talking about today.

00:23.145 --> 00:25.155
Well, the neuro, pathways

00:25.155 --> 00:29.755
that Psilocybins may be developing is a very,

00:30.135 --> 00:33.675
key area of, interest in pain management issue

00:33.675 --> 00:34.795
as well as in psychiatry.

00:35.415 --> 00:38.795
Uh, what's unique about our, case and presentation

00:38.795 --> 00:41.235
and paper that we publish is that it involves lupus,

00:41.245 --> 00:43.315
which has not been, described, before,

00:43.535 --> 00:46.795
and this is going back probably in evolution

00:46.815 --> 00:48.115
of neural pathways.

00:48.565 --> 00:52.235
Psilocybin seem to be very important, in from evolution,

00:52.895 --> 00:55.075
to, current pathways

00:55.095 --> 00:59.235
and trying to use them to help, for a variety

00:59.255 --> 01:00.275
of different syndromes.

01:00.425 --> 01:03.475
Well, this is interesting that this was a, a case report,

01:03.975 --> 01:05.635
from a patient who came in

01:06.335 --> 01:08.115
and he described what happened to him.

01:08.575 --> 01:10.715
Uh, he assumed I probably would have no interest in it,

01:10.715 --> 01:13.915
not one of, presented since, you know,

01:14.425 --> 01:15.955
psilocybins quote,

01:15.955 --> 01:17.795
magic mushrooms are illegal in California.

01:18.415 --> 01:22.075
Uh, he had, received the, the mushroom therapy

01:22.735 --> 01:25.035
in Oregon, where it is legal.

01:25.455 --> 01:28.475
Uh, but I found it very fascinating, aware

01:28.475 --> 01:30.515
of different issues from the pain world.

01:30.935 --> 01:34.035
Uh, there was one case of a gentleman in a few years ago

01:34.735 --> 01:37.635
who had an amputation of his leg,

01:37.685 --> 01:40.195
which caused chronic phantom limb pain.

01:40.625 --> 01:44.875
Nothing was working, who was essentially the pain resolved

01:44.875 --> 01:47.835
after he took psilocybin, macro dosing therapy.

01:48.055 --> 01:50.875
So it, this is kind of like the second case of something,

01:51.655 --> 01:53.995
but that, that reported that, could find,

01:54.215 --> 01:55.355
and I thought very fascinating.

01:55.355 --> 01:57.315
So we decided to write it up and research it,

01:57.315 --> 01:59.035
and that's what this article is all about.

01:59.415 --> 02:01.395
It works on serotonin receptors.

02:02.035 --> 02:03.915
Serotonin is very much involved in pain.

02:04.335 --> 02:06.755
It works actually in the frontal cortex,

02:07.415 --> 02:09.555
and, you know, from depression

02:10.015 --> 02:13.195
and a variety of different, psychiatric syndrome

02:13.195 --> 02:14.275
that's been used quite a bit.

02:14.455 --> 02:16.635
Mostly microdosing though,

02:16.635 --> 02:19.315
this gentleman actually macro dosed,

02:19.315 --> 02:20.315
which I think is unique

02:20.375 --> 02:23.595
and probably led to, more prolonged,

02:23.775 --> 02:24.995
remission from his pain.

02:25.095 --> 02:29.075
Uh, well, this study is the very first report in lupus

02:29.535 --> 02:33.635
and really an autoimmune conditions, of possible benefit

02:33.655 --> 02:36.395
of psilocybins in pain.

02:36.535 --> 02:39.315
The pain that occurs in these, syndromes,

02:40.095 --> 02:41.915
it obviously needs to be reproduced, needs

02:41.915 --> 02:45.875
to be more formally studied to really determine what,

02:46.515 --> 02:47.715
benefits could, could happen,

02:48.055 --> 02:50.755
but it's actually very exciting, in information.

02:51.495 --> 02:53.675
So I think the key takeaways are several.

02:54.415 --> 02:58.595
One is, you know, the dosing of psilocybins is

02:58.595 --> 02:59.605
Extremely important.

02:59.945 --> 03:02.925
Mostly people are microdosing for psychiatric benefits,

03:03.225 --> 03:05.205
but for pain pathways, it seems like you need

03:05.925 --> 03:08.565
possibly a much larger amount when you microdose.

03:08.575 --> 03:11.045
Maybe it lasts for hours of the benefit,

03:11.585 --> 03:14.485
but by macro dosing, which typically is between two

03:14.485 --> 03:17.205
to five grams, an episode,

03:17.405 --> 03:20.165
which causes significant amount of risk as far as,

03:20.395 --> 03:23.285
psychotic, events or, you know, bad trips

03:23.305 --> 03:24.525
or whatever you wanna call it.

03:25.065 --> 03:27.565
Um, this gentleman actually took six grams,

03:27.655 --> 03:29.565
which is a extremely high amount.

03:29.585 --> 03:31.685
And, and this was not my recommendation.

03:31.685 --> 03:35.405
He did this on his own, and he had a bad trip.

03:35.545 --> 03:37.725
He didn't, he went there to try to find himself

03:37.825 --> 03:40.845
and, thought mentally it would, help him in life,

03:41.545 --> 03:44.405
at 67, and it, that didn't occur.

03:44.465 --> 03:47.125
So there's no benefit, from that aspects for him.

03:47.385 --> 03:49.645
And actually he, it was kind of a negative experience,

03:49.695 --> 03:52.605
which we find on these high dose, therapies,

03:53.065 --> 03:56.165
but the fact that his pain result was not,

03:56.185 --> 03:59.125
we weren't looking for that, but it was, fascinating

03:59.125 --> 04:00.485
that it did, resolve it.

04:00.865 --> 04:04.725
So certainly the dosing between micro to macro dosing,

04:05.505 --> 04:07.205
is very important in the takeaway,

04:07.205 --> 04:08.965
and that's what probably needs to be studied quite a bit.

04:09.585 --> 04:11.925
Uh, secondly though is, you know, the risk of side effects,

04:11.925 --> 04:14.165
especially if you have depression or anxiety

04:14.225 --> 04:17.725
or something, the brain with his serotonin,

04:18.515 --> 04:22.325
effects could be beneficial, but it also could be negative.

04:22.325 --> 04:24.965
And so that's something that needs to be monitored as well.

04:24.965 --> 04:27.805
And he actually had a sharmin type person that monitored him

04:27.805 --> 04:29.605
through this whole event, which is very helpful

04:29.785 --> 04:31.645
and really necessary if you were to do this.

04:32.425 --> 04:33.565
Uh, the other thing is

04:33.565 --> 04:36.245
that these are currently illegal in our, in California,

04:36.265 --> 04:39.365
in most states, in the united, in the us a lot

04:39.365 --> 04:40.445
of research is going on,

04:40.555 --> 04:42.645
currently legal in Colorado and in Oregon.

04:43.505 --> 04:45.885
Um, and our experience is very limited because of that.

04:46.185 --> 04:48.245
But I do think there is definitely future need

04:48.245 --> 04:49.845
for research into this,

04:50.665 --> 04:54.045
and hopefully provide benefit for chronic pain sufferers

04:54.045 --> 04:56.405
for a variety of different, syndromes.

04:57.445 --> 05:01.965
Cytokines, which are, substances that,

05:02.925 --> 05:06.325
transmit, into the spinal fluid that seem

05:06.325 --> 05:09.405
to control pain are very important in rheumatology.

05:10.025 --> 05:11.165
Uh, interleukin six,

05:11.165 --> 05:13.605
inter other interleukins that we follow.

05:13.945 --> 05:16.765
And they seem to actually be increased in, in spinal fluid

05:17.385 --> 05:19.605
in many different pain, chronic pain syndromes.

05:19.625 --> 05:22.445
And so, you know, the targeting that instead of taking

05:23.205 --> 05:24.885
a pain pill, an anti-inflammatory

05:24.885 --> 05:28.005
and opiate, possibly cytokine therapies, possibly

05:28.695 --> 05:31.325
psilocybin therapies, all will be developed in the future

05:31.745 --> 05:34.685
and hopefully, provide relief for really chronic

05:35.195 --> 05:37.285
pain suffers, and especially people

05:37.285 --> 05:41.045
that are severely affected, with pain management.

05:41.265 --> 05:43.445
But if this is just a very preliminary observation,

05:44.895 --> 05:46.885
there are risks, just don't go do this on your own.

05:46.885 --> 05:49.005
Talk to your, doctor,

05:49.185 --> 05:50.445
you know, participate in a study.

05:50.565 --> 05:54.085
I think Johns Hopkins is doing many studies on psilocybins

05:54.085 --> 05:58.405
and pain, and I just said it's really new novel,

05:58.825 --> 06:00.485
and, I think it's looking forward.

06:01.225 --> 06:05.245
The other thing is compared to like, ayahuasca or LSD

06:05.245 --> 06:08.725
or these other things, just mushrooms are much less potent

06:08.725 --> 06:09.965
than them,

06:10.145 --> 06:12.365
and don't tend to have nearly the risk of side effects

06:12.365 --> 06:16.245
of other, hallucinogens.

06:16.545 --> 06:18.965
But it is something that obviously macro dosing,

06:19.545 --> 06:23.005
not taking like, you know, 0.1 milligram

06:23.105 --> 06:24.525
or 10 milligrams even,

06:24.825 --> 06:26.765
but this guy took actually six grams,

06:26.895 --> 06:29.405
which is a tremendous amount, for him.

06:30.105 --> 06:32.845
Um, but he had this benefit of pain relief.

06:33.345 --> 06:36.365
Uh, so you assume that he formed a neural pathway that kind

06:36.365 --> 06:38.685
of bypasses old pain pathways,

06:38.865 --> 06:42.365
and why it's relief, which is, I mean, awesome

06:42.505 --> 06:45.165
and intriguing and hopefully reproducible

06:45.165 --> 06:46.485
and maybe it will,

06:46.915 --> 06:48.965
many studies I'm sure will come in the future for this.

00:00 - Yeah, so lupus is a common disorder that we treat in rheumatology. essentially it's where the body, instead of fighting off an infection for, unclear reasons, turns on itself and tends to attack itself. it can be very much, life-threatening, affecting,

00:16 - major organ involvement. It can also cause a significant amount of pain and fatigue, as in, this case that we'll be, talking about today. Well, the neuro, pathways that Psilocybins may be developing is a very, key area of, interest in pain management issue as well as in psychiatry. what's unique about our, case and presentation and paper that we publish is that it involves lupus,

00:41 - which has not been, described, before, and this is going back probably in evolution of neural pathways. Psilocybin seem to be very important, in from evolution, to, current pathways and trying to use them to help, for a variety of different syndromes. Well, this is interesting that this was a, a case report, from a patient who came in and he described what happened to him.

01:08 - he assumed I probably would have no interest in it, not one of, presented since, you know, psilocybins quote, magic mushrooms are illegal in California. he had, received the, the mushroom therapy in Oregon, where it is legal. but I found it very fascinating, aware of different issues from the pain world. there was one case of a gentleman in a few years ago who had an amputation of his leg,

01:37 - which caused chronic phantom limb pain. Nothing was working, who was essentially the pain resolved after he took psilocybin, macro dosing therapy. So it, this is kind of like the second case of something, but that, that reported that, could find, and I thought very fascinating. So we decided to write it up and research it, and that's what this article is all about. It works on serotonin receptors. Serotonin is very much involved in pain.

02:04 - It works actually in the frontal cortex, and, you know, from depression and a variety of different, psychiatric syndrome that's been used quite a bit. Mostly microdosing though, this gentleman actually macro dosed, which I think is unique and probably led to, more prolonged, remission from his pain. well, this study is the very first report in lupus

02:29 - and really an autoimmune conditions, of possible benefit of psilocybins in pain. The pain that occurs in these, syndromes, it obviously needs to be reproduced, needs to be more formally studied to really determine what, benefits could, could happen, but it's actually very exciting, in information. So I think the key takeaways are several. One is, you know, the dosing of psilocybins is Extremely important.

02:59 - Mostly people are microdosing for psychiatric benefits, but for pain pathways, it seems like you need possibly a much larger amount when you microdose. Maybe it lasts for hours of the benefit, but by macro dosing, which typically is between two to five grams, an episode, which causes significant amount of risk as far as, psychotic, events or, you know, bad trips or whatever you wanna call it. this gentleman actually took six grams,

03:27 - which is a extremely high amount. And, and this was not my recommendation. He did this on his own, and he had a bad trip. He didn't, he went there to try to find himself and, thought mentally it would, help him in life, at 67, and it, that didn't occur. So there's no benefit, from that aspects for him. And actually he, it was kind of a negative experience, which we find on these high dose, therapies, but the fact that his pain result was not,

03:56 - we weren't looking for that, but it was, fascinating that it did, resolve it. So certainly the dosing between micro to macro dosing, is very important in the takeaway, and that's what probably needs to be studied quite a bit. secondly though is, you know, the risk of side effects, especially if you have depression or anxiety or something, the brain with his serotonin, effects could be beneficial, but it also could be negative. And so that's something that needs to be monitored as well.

04:24 - And he actually had a sharmin type person that monitored him through this whole event, which is very helpful and really necessary if you were to do this. the other thing is that these are currently illegal in our, in California, in most states, in the united, in the us a lot of research is going on, currently legal in Colorado and in Oregon. and our experience is very limited because of that. But I do think there is definitely future need

04:48 - for research into this, and hopefully provide benefit for chronic pain sufferers for a variety of different, syndromes. Cytokines, which are, substances that, transmit, into the spinal fluid that seem to control pain are very important in rheumatology. interleukin six, inter other interleukins that we follow. And they seem to actually be increased in, in spinal fluid in many different pain, chronic pain syndromes.

05:19 - And so, you know, the targeting that instead of taking a pain pill, an anti-inflammatory and opiate, possibly cytokine therapies, possibly psilocybin therapies, all will be developed in the future and hopefully, provide relief for really chronic pain suffers, and especially people that are severely affected, with pain management. But if this is just a very preliminary observation, there are risks, just don't go do this on your own. Talk to your, doctor,

05:49 - you know, participate in a study. I think Johns Hopkins is doing many studies on psilocybins and pain, and I just said it's really new novel, and, I think it's looking forward. The other thing is compared to like, ayahuasca or LSD or these other things, just mushrooms are much less potent than them, and don't tend to have nearly the risk of side effects of other, hallucinogens. But it is something that obviously macro dosing,

06:19 - not taking like, you know, 0.1 milligram or 10 milligrams even, but this guy took actually six grams, which is a tremendous amount, for him. but he had this benefit of pain relief. so you assume that he formed a neural pathway that kind of bypasses old pain pathways, and why it's relief, which is, I mean, awesome and intriguing and hopefully reproducible and maybe it will,

06:46 - many studies I'm sure will come in the future for this.

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